Morgan initially entered the porn industry as a means to pay off her bail and plea bargain after being arrested in 2000 for transporting over 100 lb (45 kg) of marijuana from Mexico into the United States. Her first sex scene was in Ed Powers' Dirty Debutantes 197.

She has been featured in HBO's A Real Sex Xtra: Pornucopia – Going Down in the Valley, Katie Morgan on Sex Toys, Katie Morgan: Porn 101, Katie Morgan's Sex Tips: Questions, Anyone?, and in the HBO documentary film Katie Morgan: A Porn Star Revealed, in which she describes having chosen the surname Morgan in reference to the alcoholic beverage Captain Morgan's Rum and the first name Katie in reference to the first name of Scarlett O'Hara of Gone with the Wind.

Morgan has been interviewed on several FM band and Sirius Satellite Radio shows, recently on King Dude, The Mike Church Show as well as XM Satellite Radio on the Opie & Anthony Show starring Jim Norton. For several years she co-hosted The Wanker Show on adult internet radio station KSEXradio.com.

In 2008 Morgan made a guest appearance on HBO's Entourage playing herself. She made her first mainstream feature film appearance in Kevin Smith's 2008 comedy, Zack and Miri Make a Porno, starring Seth Rogen and Elizabeth Banks.